Human cell research is pivotal in the pain space as it offers unparalleled insights into the underlying molecular mechanisms by bridging the gap between traditional preclinical animal models of pain and those that suffer from pain in society. Fundamental research findings using these new human tissue approaches can lead towards the development of targeted therapies. Engaging people with lived experience in this research is crucial as it ensures that the research is focused on what people actually need, leading to better health and a happier life for those dealing with pain. We will discuss some promising human cell research in development in our labs, highlighting how people with lived experience have been involved in these studies.